maioplace.blogg.se

Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Wormsĭixit, Aakanksha Tanaka, Akane Greer, Judith M. However, the possibility also exists that the individual immune modulatory molecules secreted by helminth parasites may offer a more defined therapeutic strategy. On this basis, the possibility of treating MS with helminth infection has been explored in animal models and phase 1 and 2 human clinical trials. Indeed, the global distribution of MS shows an inverse correlation to the prevalence of helminth infection. According to the old friend's hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that contributes to the increased incidence of immune mediated diseases such as Multiple Sclerosis (MS). The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms.ĭixit, Aakanksha Tanaka, Akane Greer, Judith M Donnelly, Sheila

Copyright © 2014 Australian Society for Parasitology Inc. Results obtained with the new method suggest that current predictions are likely to severely overestimate parasite diversity. These curves were then used to estimate global parasite species richness. All of the obtained models conform well to a power law curve.

This method was tested on 21 inclusive lists of parasitic worms occurring on vertebrate hosts. We show that randomly resampling host- parasite records from the existing databases makes it possible to empirically model the relationship between the number of investigated host species, and the corresponding number of parasite species retrieved from those hosts. Although this basic idea is not completely new, our approach differs from the previous ones as it treats each host species as an independent sample. Here we argue that they can also be used in the study of global parasite species richness. Accumulation curves are useful tools to estimate species diversity.